منابع مشابه
Epigenetics in Intestinal Epithelial Cell Renewal
A controlled balance between cell proliferation and differentiation is essential to maintain normal intestinal tissue renewal and physiology. Such regulation is powered by several intracellular pathways that are translated into the establishment of specific transcription programs, which influence intestinal cell fate along the crypt-villus axis. One important check-point in this process occurs ...
متن کاملEstablishment of Gastrointestinal Epithelial Organoids.
The intestinal epithelium constitutes a system of constant and rapid renewal triggered by proliferation of intestinal stem cells (ISCs), and is an ideal system for studying cell proliferation, migration, and differentiation. Primary cell cultures have proven to be promising for unraveling the mechanisms involved in epithelium homeostasis. In 2009, Sato et al. established a long-term primary cul...
متن کاملEpithelial Stem Cells, Self-renewal and Differentiation in the Intestine
The inner lining of the gut is a simple epithelium that completely selfrenews every five days because of the high mechanical and chemical stress. At the basis of the epithelial homeostasis are intestinal stem cells that are located at the bottom of crypts. Progeny is generated on a daily basis to compensate for the loss of differentiated cells that cover the villi. Under normal conditions, acti...
متن کاملWnt Signalling in Gastrointestinal Epithelial Stem Cells.
Wnt signalling regulates several cellular functions including proliferation, differentiation, apoptosis and migration, and is critical for embryonic development. Stem cells are defined by their ability for self-renewal and the ability to be able to give rise to differentiated progeny. Consequently, they are essential for the homeostasis of many organs including the gastrointestinal tract. This ...
متن کاملThe Vienna classification of gastrointestinal epithelial neoplasia.
BACKGROUND Use of the conventional Western and Japanese classification systems of gastrointestinal epithelial neoplasia results in large differences among pathologists in the diagnosis of oesophageal, gastric, and colorectal neoplastic lesions. AIM To develop common worldwide terminology for gastrointestinal epithelial neoplasia. METHODS Thirty one pathologists from 12 countries reviewed 35...
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ژورنال
عنوان ژورنال: Gastroenterology
سال: 1977
ISSN: 0016-5085
DOI: 10.1016/s0016-5085(77)80221-7